"Determinants of Long-Term Sexual HRQOL After Radical Prostatectomy Measured by a Validated Instrument", Journal of Urology. "Neoadjuvant hormonal therapy and older age are associated with adverse sexual health-related quality-of-life outcome after prostate brachytherapy ", Urology. "Comprehensive comparison of health-related quality of life after contemporary therapies for localized prostate cancer ", Journal of Clinical Oncology. "Development and Validation of the Expanded Prostate Cancer Index Composite (EPIC) for Comprehensive Assessment of Health-Related Quality of Life in Men with Prostate Cancer", Urology. *This instrument can be added on to the end of any of the other EPIC instruments to collect demographic information. Responses and comments from the development cohort were incorporated to derive the final instrument: the Expanded Prostate cancer Index Composite (EPIC). Symptom-specific bother items corresponding to each symptom item were added to elicit multi-item bother scales for each HRQOL domain. Accordingly, the UCLA-PCI was supplemented with specific items addressing irritative and obstructive voiding symptoms (the original UCLA-PCI had queried principally incontinence only in urinary function assessment), hematuria, additional bowel symptoms (to improve the suboptimal bowel function scale from the original UCLA-PCI) and hormonal symptoms. These experts, patients, and review of the literature suggested a need to augment the UCLA-PCI with items to capture additional concerns relevant to brachytherapy, external beam radiation, radical prostatectomy, and androgen deprivation. Content from the original UCLA-Prostate Cancer Index (PCI) was expanded with guidance from a development cohort of localized prostate cancer patients and an expert panel comprised of urological oncologists, radiation oncologists (including brachytherapy expertise), survey researchers, and prostate cancer nurses. The Expanded Prostate Cancer Index Composite (EPIC) is a comprehensive instrument designed to evaluate patient function and bother after prostate cancer treatment. Expanded Prostate Cancer Index Composite What is EPIC?
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